Survey on the Phosphorus Concentration in Amlodipine Tablets and Amlodipine OD Tablets
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- Furuno Takaaki
- Department of Pharmacy, Hakuryuko Hospital
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- Handa Hiroshi
- Department of Pharmacy, Hakuryuko Hospital
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- Imai Keisuke
- Department of Pharmacy, Kohsei General Hospital
Bibliographic Information
- Other Title
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- アムロジピンベシル酸塩錠およびOD錠におけるリン含有量に関する調査
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Abstract
<p>The phosphorus content of the drug was reported in the United States, and attention was paid to pharmaceutical additives. However, papers surveying the phosphorus content of drugs in Japan have not been reported. We calculated the phosphorous content in dibasic calcium phosphate hydrate (DCPH) or dibasic calcium phosphate (DCP) in amlodipine (AML) and compared the phosphorus content for each formulation. DCPH or DCP was found in all the 104 AML tablets and in 15 of the 78 AML OD tablets. On request, the pharmaceutical company revealed the amounts of DCPH or DCP in 78 of the 104 AML tablets (75.0%) and 9 of the 15 AML OD tablets (60%). The phosphorus content in AML tablets varied among the pharmaceutical companies and it tended to increase with an increase in dose. On the other hand, 63 of the 78 AML OD tablets did not contain DCPH or DCP. Furthermore, the phosphorus content in 9 of the 15 AML OD tablets containing DCPH or DCP was lower than that in AML tablets. Therefore, unnecessary phosphorus load can be avoided in dialysis patients by opting for AML OD tablets rather than AML tablets or opting for low phosphorus content AML tablets.</p>
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 43 (5), 260-266, 2017-05-10
Japanese Society of Pharmaceutical Health Care and Sciences
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Keywords
Details 詳細情報について
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- CRID
- 1390282679751510528
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- NII Article ID
- 130006733801
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed