書誌事項
- タイトル別名
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- Study on Relationship between Psychotropic Medications and Risk of Falls
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It is well known that psychotropic drugs,such as hypnotics and anxiolytics,increase the risk of falls for patients (includingfalls from high places).The present study was undertaken to evaluate the risk of falls following the taking of suchdrugs,with the focus on the benzodiazepine (BZ) family of hypnotics and anti-anxiety drugs previously reported to have ahigh risk of causing falls.When drugs of the BZ family were classified according to tmax,the mean frequency of falls differedbetween short tmax drugs and the long tmax drugs (P <0.05).This suggests that we should avoid combining shorttmax drugs (flunitrazepam,brotizolam,and triazolam) with other medication as well as the combined use of short tmaxhypnotics and drugs having potent muscle relaxant activity (bromazepam,diazepam,etizolam etc.) unless there is good justificationfor doing this.Our study showed that quazepam and rilmazafone hydrochloride are relatively safe hypnotics so far as the risk of falls isconcerned,in view of their relatively long tmax and less potent muscle relaxing activity.In some cases,the t1/2 of the drugswas correlated with the frequency of falls,suggesting that t1/2 may be a useful indicator for identifying patients requiringspecial attention and care from nurses,for instance when they are on night patrols of wards.
収録刊行物
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- 医療薬学
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医療薬学 37 (1), 49-55, 2011
一般社団法人日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679751623040
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- NII論文ID
- 130004502652
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- ISSN
- 18821499
- 1346342X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可