ラットにおけるカルベジロールとアムロジピンの用量依存的相互作用

DOI NDLデジタルコレクション 参考文献17件

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タイトル別名
  • The Dose-Dependent Pharmacokinetic Interaction between Carvedilol and Amlodipine in Rats.

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説明

The pharmacokinetic interaction between carvedilol, a nonselective β-blocking agent and amlodipine besilate, a dihydropyridine calcium-channel blocker were investigated in rats. To determine the concentration-time profile of plasma carvedilol, blood samples were obtained from the tail vein after the oral administration of carvedilol either with or without amlodipine besilate. The plasma carvedilol concentrations and pharmacokinetic parameters, comprising the area under the concentration-time curve from 0 to 24 hours (AUC0-24) showed no changes after the simultaneous oral administration of 20 mg/kg carvedilol and 5 mg/kg amlodipine besilate. In contrast, the plasma carvedilol concentrations at 6 hr-12 hr and AUC0-24 after the oral administration of carvedilol with 40 mg/kg amlodipine besilate were significantly higher than those without amlodipine besilate.<BR>These results suggested the pharmacokinetic interaction between carvedilol and amlodipine to be dependent on the dose of amlodipine.

収録刊行物

  • 病院薬学

    病院薬学 25 (1), 8-14, 1999

    一般社団法人 日本医療薬学会

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