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Efficacy of Pegylated Interferon and Ribavirin Combination Therapy in Chronic Hepatitis C and Influence of Lipid Factors
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- Harada Shinichi
- Department of Clinical Pharmacy,Faculty of Pharmaceutical Sciences,Kobe Gakuin University
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- Nawa Ayaka
- Department of Clinical Pharmacy,Faculty of Pharmaceutical Sciences,Kobe Gakuin University
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- Hamabe Wakako
- Department of Clinical Pharmacy,Faculty of Pharmaceutical Sciences,Kobe Gakuin University
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- Kim SungHi
- Department of Pharmacy,Kobe Asahi Hospital
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- Akimoto Yoko
- Department of Pharmacy,Kobe Asahi Hospital
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- Shikata Mao
- Department of Pharmacy,Kobe Asahi Hospital
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- Kimura Noriyo
- Department of Pharmacy,Kobe Asahi Hospital
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- Izawa Satoko
- Department of Pharmacy,Kobe Asahi Hospital
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- Ohtani Aya
- Department of Pharmacy,Kobe Asahi Hospital
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- Sasase Noriko
- Department of Pharmacy,Kobe Asahi Hospital
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- Ohyama Kouichirou
- Faculty of Pharmaceutical Sciences,Kobe Pharmaceutical University
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- Motoshima Masayoshi
- Faculty of Pharmaceutical Sciences,Kobe Pharmaceutical University
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- Hirai Midori
- Department of Pharmacy,Kobe University Hospital
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- Hirooka Teruko
- Clinical Pharmacy and Clinical Pharmacokinetics,Osaka University of Pharmaceutical Sciences
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- Nabeshima Shizuka
- Clinical Pharmacy and Clinical Pharmacokinetics,Osaka University of Pharmaceutical Sciences
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- Tanaka Kazuhiko
- Clinical Pharmacy and Clinical Pharmacokinetics,Osaka University of Pharmaceutical Sciences
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- Kim KeIh
- Department of Pharmacy,Kobe Asahi Hospital
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- Kim SooRyang
- Department of Gastroenterology,Kobe Asahi Hospital
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- Tokuyama Shogo
- Department of Clinical Pharmacy,Faculty of Pharmaceutical Sciences,Kobe Gakuin University
Bibliographic Information
- Other Title
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- Ｃ型慢性肝炎に対するペグインターフェロン／リバビリン併用療法の効果と脂質要因との関係
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Description
It is well known that combination therapy with interferon (IFN) and ribavirin may not achieve the full therapeutic effect in patients with high-titers(≥100 KIU/mL) for hepatitis C virus genotype 1 b.Further,high low-density lipoprotein cholesterol (LDL-C) levels are reported to be a significant indicator of the potential therapeutic effect of IFN in hepatitis C patients,though this is still controversial.In this study,we examined the serum levels of various lipids - comprising LDL-C,total-cholesterol (T-Cho),triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C)-before and after combination therapy with pegylated interferon (PEG-IFN) and ribavirin in chronic hepatitis C patients.In an end of treatment response group (ETR) group,TG levels prior to the start of the therapy were significantly lower than those in a no response (NR) group,while there were no differences in LDL-C,T-Cho and HDL-C levels between the two groups.In a sustained virological response (SVR) group,TG levels were also significantly lower than those of the NR group.These findings suggest that serum TG levels may be a significant predictive factor for the outcome of combined therapy with PEG-IFN and ribavirin in chronic hepatitis C patients.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 34 (4), 355-360, 2008
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390282679751820672
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- NII Article ID
- 110006649686
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- NII Book ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- NDL Digital Collections (NII-ELS)
- CiNii Articles
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- Abstract License Flag
- Disallowed