Docetaxel希釈濃度による過敏症発現率の相違に及ぼす検討

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  • Examination on the Effect of Docetaxel Dilution Concentration on the Hypersensitivity Revelation Rate

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Docetaxel is an extensively used taxane, frequently associated with hypersensitivity reactions (HSR). We examined whether the dilution concentration affects the incidence rate of HSR, and set up a concentration that can control HSR. We also established management of HSR that were caused by docetaxel.<br>Retrospective analysis was performed at a single institution in 471 consecutive patients treated with the regimen, including docetaxel for breast cancer, gastric cancer, non-small-cell lung cancer, prostate cancer and skin cancer from 2006 to 2011. Among 471 patients, 90 were in the 250 mL group and 381 were in the 500 mL group.<br>The rate of HSR was 14.4% in the 250 mL group vs 2.4% in the 500 mL group (P<0.01). Regarding the duration of HSR, there was no significant difference between the two groups (1.69 ± 0.75 cycles vs 2.22 ± 1.71 cycles). The seriousness of HSR was similar in the two groups (250 mL groups; G1:61.5%, G2:30.8%, G3/G4:7.7% vs 500 mL groups; G1:77.8%, G2:11.1%, G3/G4:11.1%). Moreover, no difference was found in the rate of HRS below 0.02 w/v% standard concentration, when all patients were divided into another two groups (above the standard concentration; Above Group, below the standard concentration; Below Group).<br>In conclusion, our present data suggest that the dilution concentration of docetaxel strongly affects the rate of HSR. Moreover, if the dilution concentration of docetaxel is below 0.02 w/v% (cutoff value), it is suggest that HSR can be controlled. These findings show that the dilution concentration of docetaxel can become a tool that for controlling HRS in addition to the existing premedication.

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  • 医療薬学

    医療薬学 38 (9), 547-558, 2012

    一般社団法人日本医療薬学会

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