A case of the elimination half-life of valproic acid in a newborn infant.

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  • 胎盤移行したバルプロ酸の新生児期における消失半減期（１例報告）

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Abstract

The pharmacokinetic parameters of valproic acid (VPA) transferred via the placenta were clinically investigated in a newborn infant born to an epileptic mother. The newborn, delivered at about 37-week gestation, was a healthy male (birth weight 2, 500g). The Apgar score was 6. The serum levels of VPA between 6 hours and 8 days after birth were monitored by the FPIA method. The elimination pattern was mono-exponential, and the pharmacokinetic parameters were t 1/ 2= 45.7 hr and Kel= 0.0152 hr-1 according to the one compartment model.

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