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Comparison of Drug Release Characteristics between Brand Name and Generic Cataplasms Using Artificial Sweat as Testing Medium
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- Tairabune Tomohiko
- Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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- Shimamura Takeshi
- Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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- Ueda Hideo
- Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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- Numajiri Sachihiko
- Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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- Kobayashi Daisuke
- Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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- Morimoto Yasunori
- Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University Research Institute of TTS Technology
Bibliographic Information
- Other Title
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- 人工汗を用いた放出試験による先発パップ剤と後発パップ剤の比較
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Description
The drug release and swelling characteristics of cataplasms may be evaluated using artificial sweat. In our study, these characteristics were compared among brand name and generic cataplasms containing nonsteroidal anti-inflammatory drugs (NSAIDs ; indomethacin (IM) (8 products), ketoprofen (KP) (7 products) and flurbiprofen (FP) (4 products)) using artificial sweat and the apparatus described in JP 14 Dissolution Test Method 2. For cataplasms containing IM and FP, the degree of swelling of generic products was less than that of brand name products but there was no significant difference in release rate. On the other hand, for KP-containing cataplasms, disintegration of the base material was observed for three of the four generic products tested, and all four had higher release rates than the brand name products. Thus, the drug release testing method used in the present study showed that the release and swelling characteristics differed between brand name and generic cataplasms and we felt that it was a useful way of evaluating their quality.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 30 (11), 723-729, 2004
Japanese Society of Pharmaceutical Health Care and Sciences
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Keywords
Details 詳細情報について
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- CRID
- 1390282679752207232
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- NII Article ID
- 110001171444
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- NII Book ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- IRDB
- Crossref
- NDL Digital Collections (NII-ELS)
- CiNii Articles
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- Abstract License Flag
- Disallowed