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Quality Test of Sephalexin Capsules
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- KISHI HIROE
- Department of Pharmacy, Osaka University Hospital
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- ONO TAKESHI
- Department of Pharmacy, Osaka University Hospital
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- MORIMOTO KIMIKO
- Department of Pharmacy, Osaka University Hospital
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- HIRAOKA EIICHI
- Department of Pharmacy, Osaka University Hospital
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- KOMEMUSHI SADAO
- Faculty of Pharmaceutical Sciences, Osaka University
Bibliographic Information
- Other Title
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- セファレキシンカプセルの品質試験
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Description
The quality of 6 brands of cephalexin capsules (250mg) was evaluated by dissolution test (U. S. P. XIX) and some other tests in vitro. The dissolution rate of 1 (product F) of the 6 kinds of capsules was about 57% in the first 15 minutes, showing a statistically significant difference (p<0. 01) between the rates (nearly 100%) for the remaining 5. Further, the variations of weight, content and dissolution rate were larger in product F than in the others. The rate of in vitro dissolution may be a decisive factor in the in vivo absorption and excretion. From the viewpoint of uniformity of therapeutic effect, product F is undesirable.
Journal
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- Japanese Journal of Hospital Pharmacy
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Japanese Journal of Hospital Pharmacy 2 (3), 154-158, 1976
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390282679752281344
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- NII Article ID
- 110001796631
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- NII Book ID
- AN00002794
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- ISSN
- 21859477
- 03899098
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- Data Source
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- JaLC
- Crossref
- NDL Digital Collections (NII-ELS)
- CiNii Articles
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- Abstract License Flag
- Disallowed