セファレキシンカプセルの品質試験

DOI NDLデジタルコレクション

書誌事項

タイトル別名
  • Quality Test of Sephalexin Capsules

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説明

The quality of 6 brands of cephalexin capsules (250mg) was evaluated by dissolution test (U. S. P. XIX) and some other tests in vitro. The dissolution rate of 1 (product F) of the 6 kinds of capsules was about 57% in the first 15 minutes, showing a statistically significant difference (p<0. 01) between the rates (nearly 100%) for the remaining 5. Further, the variations of weight, content and dissolution rate were larger in product F than in the others. The rate of in vitro dissolution may be a decisive factor in the in vivo absorption and excretion. From the viewpoint of uniformity of therapeutic effect, product F is undesirable.

収録刊行物

  • 病院薬学

    病院薬学 2 (3), 154-158, 1976

    一般社団法人 日本医療薬学会

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