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Research for the Crystal Material Produced in the Continuous Infusion Line of Midazolam(Dormicum) and Butorphanol(Stadol).
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- YOSHIDA HISAHIRO
- Department of Pharmacy, Yamaguchi University Hospital
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- TAKABA DAIKI
- Department of Pharmacy, Yamaguchi University Hospital Medical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- UCHIDA YUTAKA
- Department of Pharmacy, Yamaguchi University Hospital
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- ISHIMOTO KEIZO
- Department of Pharmacy, Yamaguchi University Hospital
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- SHIMA KATSUHITO
- Medical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- OKANO YOSHIROU
- Medical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- KAMIYA AKIRA
- Department of Pharmacy, Yamaguchi University Hospital
Bibliographic Information
- Other Title
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- ミダゾラム（ドルミカム）・ブトルファノール（スタドール）持続注入回路内に析出した結晶成分の分析とその成因
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Description
Resolution of the problems appearing in the clinical departments with relation to drug utility is a very important task for hospital pharmacists. The chief nurse of the surgery section recently asked us to examine the crystal material often appearing in the continuous infusion line of Dormicum®-Stadol® (2: 1) several hours after infusion of other medicines. The crystals were examined by high performance liquid chromatography. The retention time of the crystals was the same as that of midazolam, and the crystals were identified to be midazolam. The main cause of the formation of crystals was found to be the rise in the pH of midazolam injection due to the mixing with butorphanol injection. Moreover, the changes in ion strength and ion components in the solution affected the appearance of the crystals. Thus, midazolam should not be infused with butorphanol. If a mixture of midazolam and other medicines must be infused continuously, medical workers should check for the appearance of the crystals.
Journal
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- Japanese Journal of Hospital Pharmacy
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Japanese Journal of Hospital Pharmacy 23 (6), 531-538, 1997
Japanese Society of Pharmaceutical Health Care and Sciences
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Keywords
Details 詳細情報について
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- CRID
- 1390282679752428288
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- NII Article ID
- 110001799696
- 130004103176
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- NII Book ID
- AN00002794
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- ISSN
- 21859477
- 03899098
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- NDL Digital Collections (NII-ELS)
- CiNii Articles
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- Abstract License Flag
- Disallowed