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Drug Incompatibility of Amlodipine under Basic Conditions in a Simple Suspension Method
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- Yuzuki Shota
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Minegaki Tetsuya
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Hakui Rieko
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Fujii Naoko
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Hamada Miki
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Wakabayashi Miki
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Bando Kinuko
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Miyanishi Ryoka
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Momii Kana
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Tsujimoto Masayuki
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
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- Nishiguchi Kohshi
- Department of Clinical Pharmacy, Kyoto Pharmaceutical University
Bibliographic Information
- Other Title
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- アムロジピンベシル酸塩製剤と酸化マグネシウム製剤の同時簡易懸濁による主薬量の変動
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Description
For patients experiencing dysphagia, especially those who have undergone neurosurgery and have been prescribed multiple medications, the simple suspension method is a useful way of simultaneously administering multiple drugs. However, little is known about the incompatibility of drugs administered simultaneously according to this method. In the present study, we assessed the amount of active pharmaceutical ingredients remaining in the suspension on suspending sodium valproate, warfarin potassium, amlodipine besylate, and magnesium oxide simultaneously. When the Norvasc®OD tablet was suspended with Magmitt® tablet, the recovery amount of amlodipine remaining in the suspension decreased significantly in an exposure time-dependent manner. The decrease in amlodipine was also observed when the Norvasc®OD tablet or amlodipine besylate was suspended in a basic buffer (pH 10). Furthermore, the decrease was accompanied by degradation of amlodipine. These results suggest that the degradation of amlodipine caused by the increase in pH led to the decrease in amlodipine. In conclusion, the results of this study suggest that it is necessary to pay attention to simultaneous suspension of amlodipine and drugs that increase the pH of the suspension.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 40 (4), 252-257, 2014
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390282679752616960
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- NII Article ID
- 130005062834
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed
