Compatibility of Sulfamethoxazole-Trimethoprim Granules with Other Preparations

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  • スルファメトキサゾール・トリメトプリム顆粒剤の配合変化

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Apparent compatibility of sulfamethoxazole-trimethoprim granules (ST) with 41 drugs was tested under medium (20°, RH 75%) and the worst condition (30°, RH 92%). There was no change in appearance of ST wrapped by itself in chartula under medium condition. But, under the worst condition, ST wrapped mechanically in laminated glassine was moistened in 10 days. Of the mixtures of ST and 41 drugs wrapped in laminated glassine, 7 mixtures showed a moistening tendency in 14 days under medium condition. Mixtures with 25 other drugs showed the same tendency under the worst condition, but mixing did not cause increase in moistening tendency. In conclusion, ST remains stable in the climate of Japan even if it is combined with many other drugs.

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