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Study on Improving Efficiency in Preparation of TAXOTERE Injection
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- Tsutsumi Kazuki
- Department of Pharmacy,Kurume University Hospital
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- Hada Masao
- Department of Pharmacy,Social Insurance Kurume Daiichi Hospital
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- Ohmitsu Masao
- Center for Education of Clinical Pharmacy ,Daiichi University,College of Pharmaceutical Sciences
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- Tazuya-Murayama Keiko
- Department of Design of Pharmaceutics ,Daiichi University,College of Pharmaceutical Sciences
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- Nose Ikuhiro
- Department of Pharmacy,Social Insurance Kurume Daiichi Hospital
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- Tsuruta Mieko
- Department of Pharmacy,Kurume University Hospital
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- Mishima Motohiro
- Department of Design of Pharmaceutics ,Daiichi University,College of Pharmaceutical Sciences
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- Morita Keiko
- Center for Education of Clinical Pharmacy ,Daiichi University,College of Pharmaceutical Sciences
Bibliographic Information
- Other Title
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- タキソテール注射液調製時における効率化の検討
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Description
In order to improve efficiency in the preparation of TAXOTERE® injection for alcohol hypersensitive patients,we investigated its dissolution in warmed saline or 5% glucose solution.Solutions were heated to 3 different temperatures : 25°C,55 °C and 70°C.At 55°C and 70°C,for both warmed saline and 5% glucose,uniform TAXOTERE® premix solutions were obtained within 1 minute,while 10 minutes or more was required at 25°C.Further,to obtain uniform TAXOTERE® premix solutions at 55°C and 70°C only gentle mixing was necessary.There was no need for vigorous shaking.<br>We then investigated the stability of docetaxel hydrate in warmed TAXOTERE® premix solutions using HPLC.No peak for docetaxel hydrate was observed in the case of heating at 25°C for 24 hours or for heating at 55°C heating for 3 hours,for both warmed saline and 5% glucose.At 70°C,peaks assumed to be those of catabolites of docetaxel hydrate were apparent after 60 minutes.<br>In conclusion,we consider that the use of warmed saline or 5% glucose solution at 55°C in the preparation of TAXOTERE® injection for alcohol hypersensitive patients can shorten the preparation time,and greatly raise efficiency in preparation.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 35 (6), 431-435, 2009
Japanese Society of Pharmaceutical Health Care and Sciences
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Keywords
Details 詳細情報について
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- CRID
- 1390282679752762112
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- NII Article ID
- 10025973585
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- NII Book ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
