Study on Initial Dosage Setting of Vancomycin Injection.
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- MAEDA YORINOBU
- Department of Pharmacy, Chugoku Rousai General Hospital
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- KONISHI TOSHIO
- Department of Pharmacy, Chugoku Rousai General Hospital
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- SAIONJI SHINJI
- Department of Pharmacy, Chugoku Rousai General Hospital
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- FUNAKOSHI SACHIYO
- Department of Pharmacy, Chugoku Rousai General Hospital
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- NAKAMURA MAMORU
- Department of Pharmacy, Chugoku Rousai General Hospital
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- NII WAKAKO
- Department of Pharmacy, Chugoku Rousai General Hospital
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- MASAKI FUMIKO
- Department of Pharmacy, Chugoku Rousai General Hospital
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- TSUKIAI SATSUKI
- Department of Pharmacy, Chugoku Rousai General Hospital
Bibliographic Information
- Other Title
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- バンコマイシンの初期投与法の検討
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Abstract
To elucidate the current status of the dosage regimen of vancomycin, we reviewed its therapeutic drug monitoring (TDM) data obtained from 99 patients undergoing vancomycin treatment at the Chugoku Rousai Hospital. The plasma concentrations of vancomycin at one dosage under 750 mg deviated from its therapeutic ranges (the level at one hour after the end of infusion: 25-40μg/mL, trough level:≤10 μg/mL). Therefore, the dosing interval at a uniform dosage of 1000 mg was calculated from a vancomycin nomogram reported by Moellering et al., and the utility of the dosing interval at the uniform dosage of 1000 mg combined with a creatinine clearance nomogram reported by Nielsen et al. was examined. As a result, the plasma levels of 66 percent of the subjects were controlled within the accepted therapeutic ranges in the early stage. Accordingly, the nomogram of vancomycin prepared as an indication in the early stage in our hospital was thus concluded to be clinically acceptable.
Journal
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- Japanese Journal of Hospital Pharmacy
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Japanese Journal of Hospital Pharmacy 25 (5), 517-524, 1999
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390282679752848640
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- NII Article ID
- 110001166914
- 130004299725
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- NII Book ID
- AN00002794
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- ISSN
- 21859477
- 03899098
- http://id.crossref.org/issn/03899098
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- Abstract License Flag
- Disallowed