シベンゾリンの適正投与に対するＴＤＭの寄与

DOI NDLデジタルコレクション 参考文献8件

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  • TDM Helps Ensure the Proper Administration of Cibenzoline

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Owing to their narrow therapeutic range, most antiarrhythmic agents require Therapeutic Drug Monitoring (TDM). Though TDM is an effective tool for adjusting the individual dosage to the optimum level, no study has shown that TDM is useful for dose adjustment in the case of cibenzoline. The aim of this study was thus to evaluate the usefulness of TDM in cibenzoline therapy.<BR>In the National Cardiovascular Center, TDM was introduced for cibenzoline in 1998. This resulted in reductions in mean serum concentrations and mean doses, and very few adverse effects have been reported. Thanks to dosage adjustment based on TDM, there was a decrease in the proportion of patients having serum concentrations of above 400 ng/mL from 2000 onwards. These results suggest that TDM is an effective tool for preventing cibenzoline toxicity and that it helps to ensure that cibenzoline is administered properly.

収録刊行物

  • 医療薬学

    医療薬学 31 (5), 406-409, 2005

    一般社団法人日本医療薬学会

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