Stability of Urokinase in Sodium Cefalotin Preparations

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  • セファロチンナトリウム製剤中におけるウロキナーゼ製剤の安定性

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Stability of urokinase (UM) in sodium cefalotin preparations (CET) was investigated in terms of the agent's appearance, change of pH, and activity as determined by fibrin-plate Method and Chandler's Loop method. Electrophoresis was also used in the same study. The results are summarized as follows:<BR>1) UM activity was significantly decreased after mixing. However, residual potency of CET remained above 96% even 24 hours after mixing. 2) UM was unstable in CET in various concentrations or IV infusions. Same tendency was observed with UM in standard CET. 3) From the results of electrophoresis, it was found that CET contained some foreign matters.<BR>It was also found in the above study that CET or foreign matters in CET caused the decrease in UM activity. It is, therefore, concluded that UM is incompatible, with CET.

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