Screening of Furanocoumarin Derivatives in Foods and Crude Drugs by Enzyme-Linked Immunosorbent Assay
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- Saita Tetsuya
- Department of Pharmacy, Saga University Hospital
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- Fujito Hiroshi
- Department of Pharmacy, Saga University Hospital
Bibliographic Information
- Other Title
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- 酵素免疫測定法による食物・生薬中のフラノクマリン類含量のスクリーニング
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Description
Furanocoumarin derivatives such as bergamottin and 6',7'-dihydroxybergamottin are inhibitors of CYP3A4 and have been isolated from grapefruit juice. We developed a sensitive and specific enzyme-linked immunosorbent assay for these furanocoumarin derivatives and used it for screening a large number of citrus fruits, vegetables and crude drugs for them. On testing the juice and peel of 25 citrus fruits, significant reactivity was observed with the juice of 4 of them : sweetie, melogold, banpeiyu pummelo and red pummelo and in the case of peel, significant reactivity was observed for 4 fruits : sweetie, melogold, sour pummelo and natsudaidai. For most of the citrus fruits, the peel showed a stronger reaction than the juice. Seven vegetables were tested and only slight reactivity was observed for 4 of them : parsley, celery, Italian parsley and mitsuba. Among the twenty crude drugs tested, significant reactivity was observed for 2 : angelica dahurica root (byakushi) and bitter orange peel (touhi). These findings suggest that 4 of the citrus fruits and 2 of the crude drugs tested would exhibit strong drug interactions.
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 32 (7), 693-699, 2006
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390282679754045056
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- NII Article ID
- 110004740988
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- NII Book ID
- AA11527197
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- COI
- 1:CAS:528:DC%2BD28Xotlegt7c%3D
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- NDL Digital Collections (NII-ELS)
- CiNii Articles
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- Abstract License Flag
- Disallowed