Determination of Drug Levels in Acute Bromvalerylurea Intoxication.

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  • KOYAMA KAZUHIRO
    Institute for Clinical Research The Second Tokyo National Hospital Department of Pharmacy The Second Tokyo National Hospital
  • KIKUNO TAKAAKI
    Emergency and Critical Care Unit The Second Tokyo National Hospital
  • ICHIKIZAKI KIYOSHI
    Emergency and Critical Care Unit The Second Tokyo National Hospital
  • MURAKOSHI KOUJI
    Institute for Clinical Research The Second Tokyo National Hospital Department of Pharmacy The Second Tokyo National Hospital
  • SHIROKAWA HIROMI
    Department of Pharmacy The Second Tokyo National Hospital
  • ISHII SOUICHI
    Department of Pharmacy The Second Tokyo National Hospital

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Other Title
  • ブロムワレリル尿素急性薬物中毒例における血中濃度の検討

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Bromvalerylurea and coadministered drugs in serum, gastric fluid and urine were measured by HPLC in 10 cases of acute intoxication. In four cases, bromvalerylurea was collected and in six cases, bromvalerylurea and other drugs were collected.<BR>Morover, 5 microgram/ml of bromvalerylurea in serum was suggested to depress the conscious level of patients. Elimination half-lives were 3.6 hr under treatment of forced diuresis. The bromvalerylurea level in the fatal case was 189.4 microgram/ml in serum.

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