Study to Determine if 33 Gauge Tapered Injection Needle Affects Hypoglycemic Properties and Crystalline Structure of Neutral Protamine Hagedorn (NPH) Insulin Particles of Insulin Preparations Passed through it

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  • ３３ゲージのテーパー型注射針を懸濁インスリン製剤が通過したときのＮＰＨ結晶の形状とインスリンの血糖降下作用への影響について

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The Nanopass®33 micro-tapered needle (MT 33 G, Terumo Corp., Tokyo, Japan) is tapered in form : 33 G at the tip end and 28 G at the cartridge end. We examined the structure of insulin crystals in insulin suspensions before and after passing through the MT 33 G needle to determine if there were any changes in it that might adversely affect the pharmacodynamics and action of insulin. We also examined the hypoglycemic effect of insulin in dogs after it had passed through a MT 33 G needle to see if it had been modified by it.<BR>No changes were observed in the insulin crystal structure when the insulin preparation in a syringe was discharged at a rate of 10 units/sec through the MT 33 G needle connected to it. Also, when insulin was administered to dogs, there was no significant difference between the MT 33 G and the Micro-FineTM Plus, 31G, Thin Wall needle (Nippon Becton Dickinson Co., Ld., Tokyo, Japan) as regards the blood insulin and blood glucose levels measured.

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