Study on Clinical Usefulness of Chemotaxis Chamber Method in Leukocyte Migration Test for Identification of Allergenic Drugs

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  • 薬物アレルギー起因薬検出における白血球遊走試験 (ケモタキシス·チャンバー法)の臨床的有用性の検討
  • Study on clinical usefulness of chemotaxis chamber method in leukocyte migration test for identification of allergenic drugs—Comparison between chemotaxis chamber method and agarose plate method
  • -アガロース·プレート法とケモタキシス·チャンバー法の比較解析-
  • -Comparison between Chemotaxis Chamber Method and Agarose Plate Method-

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We performed a comparison between leukocyte migration tests performed by the chemotaxis chamber method (LMTchamber) and the agarose plate method (LMT-agarose) to study the usefulness of the LMT-chamber method in the identification of causative drugs in drug allergies.<br>For LMT-agarose,the positive rate among 210 patients suspected of hypersensitivity to drugs (subject patients) was 67.6 % and for the LMT-chamber the positive rate among 197 subject patients was 81.2%,a significantly higher positive rate for the latter (p<0.001,χ2-test).The positive rate for LMT-agarose was 6.9% in 102 patients without hypersensitivity to drugs (control patients) and 9.8% for the LMT-chamber in 82 control patients,but this difference was not significant.In addition,the LMT-chamber produced a higher positive rate than LMT-agarose for all hypersensitivity symptoms and all efficacy categories of the suspected drugs.It also produced a significantly higher positive rate than LMT-agarose in subject patients without addition of self serum (p<0.05,χ2-test) and there were no significant differences between males and females or young and old persons,as there were in the case of LMT-agarose.<br>Our findings indicate that the LMT-chamber may be more sensitive than LMT-agarose in identifying the causative drug in drug allergies and more useful than LMT-agarose for many hypersensitivity symptoms and suspected drugs.In addition,the LMT-chamber is much less influenced than LMT-agarose as regards patient’s own serum,or by sex and age.

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