Survey on Awareness of Drug Interactions among Medical Professionals-Interaction between Grapefruits and Drugs-

DOI NDL Digital Collections 2 Citations 4 References
  • Kowari Koji
    Kanagawa Drug Interactions Research Association Department of Pharmacy, St. Marianna University School of Medicine Toyoko Hospital
  • Yanagawa Chuji
    Kanagawa Drug Interactions Research Association Department of Pharmacy, St. Marianna University School of Medicine Toyoko Hospital
  • Sagawa Ken-ichi
    Kanagawa Drug Interactions Research Association Department of Pharmacy, Kitasato University Hospital
  • Ikeda Tsutomu
    Kanagawa Drug Interactions Research Association Department of Pharmacy, Saiseikai Wakakusa Hospital
  • Kosaka Yoshio
    Kanagawa Drug Interactions Research Association Department of Pharmacy, Nippon Medical School Second Hospital
  • Yoda Keiji
    Kanagawa Drug Interactions Research Association Department of Pharmacy, International Goodwill Hospital
  • Abe Hiroshi
    Kanagawa Drug Interactions Research Association Department of Pharmacy, Ebina General Hospital
  • Sato Toru
    Kanagawa Drug Interactions Research Association Department of Pharmacy, Kawasaki Saiwai Hospital
  • Kouno Hiromitsu
    Kanagawa Drug Interactions Research Association Department of Pharmacy, Teikyo University School of Medicine Mizonokuchi Hospital
  • Shibata Tetuichi
    Kanagawa Drug Interactions Research Association Nihon Pharmaceutical University

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Other Title
  • 医療従事者の薬物相互作用に対する意識調査―グレープフルーツと薬物の相互作用について―
  • Interaction between Grapefruits and Drugs
  • グレープフルーツと薬物の相互作用について

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Abstract

Drug interactions broadly fall into two categories : drug-drug interactions, which occur when two or more drugs react with each other, and drug-food/beverage interactions, which occur when drugs react with a food or beverage taken concurrently. These interactions may profoundly affect drug pharmacokinetics, pharmacologic actions and efficacy, and may cause adverse reactions. To avoid the risks of drug interactions, it is important that not only medical professionals but also patients be fully aware of potential interactions, and also that consistent information be given to patients. The achievement of these two objectives can reduce the frequency of the adverse effects and improve outcomes.<BR>We selected the example of the widely discussed interactions between grapefruits and certain drugs and investigated the extent to which medical staff (doctors, nurses, dietitians, and pharmacists) were aware of them and informed their patients about them, by means of a questionnaire. From the findings, it was clear that awareness of the interactions among medical professionals varied greatly and the amount of information given to patients also varied greatly, implying that awareness of the interactions and the information provided to patients on them were both inadequate.<BR>The absence of consistent information will lead to patient confusion and is disadvantageous from a therapeutic viewpoint. We therefore believe that an important role of pharmacists' in drug therapy is to proactively provide appropriate information on drug interactions to medical professionals and patients before they have the chance to occur.

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