Compatibility of Soldactone in intravenous infusions.

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  • 輸液中におけるソルダクトンの配合変化

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Potassium canrenoate, the active ingredient of intravenous additive Soldactone®, is likely to be deposited at lower pH, and the product is known to cause a physicochemical incompatibility with many other injections. Soldactone was mixed with many kinds of intravenous (IV) fluids, and the changes in the pH and appearance of the mixture were observed.<BR>A precipitate was produced immediately after combination with acidic IV fluids such as electrolytes fluid including dextrose or fructose and amino acid fluids. Further, since Soldactone 200 mg could be mixed with Sorbit Hartmann® or 5 % dextrose fluid, the compatibility on addition of the third intravenous additive to this intravenous (IV) admixture was examined. As a result, 30 to 40% of 188 intravenous additives studied showed a physical and chemical incompatibility upon mixing.<BR>Thus, the pharmacists, when preparing the IV admixture, should recommend use of as few additives as possible in IV fluids, since the risk of potential problem increases in parallel with the number of additives.

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