Compatibility of Wintermin fine granules and magnesium oxide.

DOI 2 Citations
  • INADA SETSUKO
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • OKADA KOJI
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • OHTA TOSIO
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • NISIDA KATSUJI
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • MIZUNO MASANAO
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital

Bibliographic Information

Other Title
  • ウインタミン細粒と酸化マグネシウムの配合変化

Description

The compatibility of Wintermin® fine granules consisting of chlorpromazine phenolphthalinate and magnesium oxide was investigated by sensory test, and the residual amount of chlorpromazine was measured with high-performance liquid chromatography. Although the coloration to pink in the preparation was observed after preservation under medium (20°C, RH 75%) and severe (30°C, RH 92%) conditions, no change in the amount of chlorpromazine under any condition tested was noticed.<BR>It was also found from the chromatogram that a slight amount of phenolphthalein was contaminated in Wintermin®fine granules. Moreover, no change was detected in the compatibility test of chlorpromazine hydrochloride and magnesium oxide under the severe condition.It was, therefore, suggested that the interaction between phenolphthalein and magnesium oxide alkalized by moisture was responsible for the coloration in the preparation of Wintermin®fine granules and magnesium oxide.

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Details 詳細情報について

  • CRID
    1390282679754560256
  • NII Article ID
    130004299115
  • DOI
    10.5649/jjphcs1975.16.107
  • ISSN
    21859477
    03899098
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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