初期慢性関節リウマチ患者に対するＬｏｂｅｎｚａｒｉｔ　ｄｉｓｏｄｉｕｍ（ＣＣＡ）投与前後の滑膜組織の免疫組織学的検討

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  • Immunocytochemical evaluation of the effect of a newly developed immunomodulating drug(CCA) to the synovial tissue of patients in the early stage of rheumatoid arthritis(RA)

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To evaluate the effect of a newly developed immunomodulating drug, CCA in the early stage of RA, we examined histological features, with the aid of immunohistochemical markers, in the synovial tissue of the knee joint of RA patients (within one year after onset of disease) on two occasions, that is, before and after the administration of CCA at the dose of 240 mg per day for 6 to 24 weeks. In 10 cases examined, 3 of them took as favorable course and 3 took a fair course and the remaining did not change by the administration of CCA. Immunostaining of tissues from the improved patients revealed that (1) the total number of inflammatory cells were decrease after CCA treatment, (2) the accumulation of lymphocytes, mostly B cells, in the synovia, was not detected prior to CCA administration.<BR>Although it was impossible to count the number of HLA/DR positive cells which were consisted of various kinds of cells such as macrophages, B lymphocytes, a part of synovial lining cells, T lymphocytes and interstitial cells, the quantitative change of these cells was parallel to the total cell number in synovial tissues.

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  • 炎症

    炎症 11 (4), 361-367, 1991

    日本炎症・再生医学会

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