Study on changes in blood gold concentration and efficacy & safety of oral gold compound (auranofin) as replacement of injectable gold (GST) in patients with rheumatoid arthritis.
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- Ochi Takahiro
- Dept. Orthop. Surg., Osaka Univ. School of Med.
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- Ono Keiro
- Dept. Orthop. Surg., Osaka Univ. School of Med.
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- Shichikawa Kanji
- Yukioka Hosp
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- Yukioka Masao
- Yukioka Hosp
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- Maeda Akira
- Osaka Minami Natl. Hosp
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- Murata Norikazu
- Osaka Minami Natl. Hosp
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- Komatsubara Yoshio
- Osaka Geriatric Diseases Center
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- Iwase Rokuro
- Hoshigaoka Kosei-Nenkin Hosp
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- Ogura Hideto
- Osaka Pref. Hosp
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- Akabori Osamu
- Kansai Rosai Hosp
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- Kitano Kozo
- Kansai Rosai Hosp
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- Ota Hiroshi
- Osaka JR Hosp
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- Hirooka Jun
- Osaka JR Hosp
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- Cho Hideyuki
- Yao City Hosp
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- Okayama Takashi
- Izumisano City Hosp
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- Takeda Toshiya
- Izumisano City Hosp
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- Harada Kazutaka
- Izumiotsu City Hosp
Bibliographic Information
- Other Title
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- 慢性関節リウマチ治療における注射金剤（ＧＳＴ）から経口金剤（オーラノフィン）への切り換えに伴う血中濃度の変化と有効性および安全性の検討
Description
To determine if rheumatoid arthritis patients on gold sodium thiomalate (GST) can be maintained on auranofin (AF), we examined a group 111 patients, who had been stable on GST.<BR>The patients were randomized to receive either AF 6 mg daily, or continued GST. Patients eligible for study showed no difference in clinical outcome after 6 months of treatment.<BR>On-therapy conditions in the 2 groups were similar, with the exception of diarrhoea in 29.8% of the AF-treated group.<BR>And there were no correlation between blood gold concentration and safety & efficiency.<BR>This study shows that AF may be substituted for GST during rheumatoid arthritis therapy.
Journal
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- Ensho
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Ensho 8 (6), 563-570, 1988
The Japanese Society of Inflammation and Regeneration
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Details 詳細情報について
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- CRID
- 1390282679761281024
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- NII Article ID
- 130003710015
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- ISSN
- 18844006
- 03894290
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
