慢性関節リウマチ治療における注射金剤（ＧＳＴ）から経口金剤（オーラノフィン）への切り換えに伴う血中濃度の変化と有効性および安全性の検討

DOI

書誌事項

タイトル別名
  • Study on changes in blood gold concentration and efficacy & safety of oral gold compound (auranofin) as replacement of injectable gold (GST) in patients with rheumatoid arthritis.

説明

To determine if rheumatoid arthritis patients on gold sodium thiomalate (GST) can be maintained on auranofin (AF), we examined a group 111 patients, who had been stable on GST.<BR>The patients were randomized to receive either AF 6 mg daily, or continued GST. Patients eligible for study showed no difference in clinical outcome after 6 months of treatment.<BR>On-therapy conditions in the 2 groups were similar, with the exception of diarrhoea in 29.8% of the AF-treated group.<BR>And there were no correlation between blood gold concentration and safety & efficiency.<BR>This study shows that AF may be substituted for GST during rheumatoid arthritis therapy.

収録刊行物

  • 炎症

    炎症 8 (6), 563-570, 1988

    日本炎症・再生医学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679761281024
  • NII論文ID
    130003710015
  • DOI
    10.2492/jsir1981.8.563
  • ISSN
    18844006
    03894290
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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