好中球細胞死の多様性と制御

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  • Heterogeneity of human neutrophil cell death and its regulation.

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We found that hyposmotic conditions rapidly induce human neutrophil apoptosis. In an attempt to define the molecular events involved in neutrophil apoptosis, we investigated the effect of protein kinase inhibitors and a protein synthesis inhibitor. Neutrophils undergoing apoptosis induced under different conditions (i.e, aging, hyposmotic conditions, and TNFα) exhibited various responses to these inhibitors suggesting that a variety of distinct molecular events occur in neutrophil apoptosis induced by different stimuli.<BR>On the other hand, we also found that activated neutrophils with phorbol 12-myristate 13-acetate (PMA) showed morphological changes quite different from those of typical apoptosis or necrosis due to oxygen radicals (especially hydroxyl radical) produced by neutrophil itself through PKC activation. A certain population of neutrophils phagocytosing opsonized zymosan also showed changes similar to those observed in PMA treated cells. Although the precise biological implication of the hyperactivation induced cell suicide is unclear, a variety of distinct molecular events characteristic of human neutrophil apoptosis may contribute to prevent prolongation of inflammation by eliminating unwanted cells.

収録刊行物

  • 炎症

    炎症 16 (1), 29-36, 1996

    日本炎症・再生医学会

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