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<I>Percutaneous absorption and anti-inflammatory activity of indomethacin in ointment</I>
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- Wada Yasushi
- Tokyo Research Laboratories, Kowa Co. Ltd.
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- Etoh Yoshinori
- Tokyo Research Laboratories, Kowa Co. Ltd.
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- Ohira Akiyoshi
- Tokyo Research Laboratories, Kowa Co. Ltd.
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- Kimata Hideki
- Tokyo Research Laboratories, Kowa Co. Ltd.
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- Koide Takashi
- Tokyo Research Laboratories, Kowa Co. Ltd.
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- Ishihama Hiroshi
- Tokyo Research Laboratories, Kowa Co. Ltd.
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- Mizushima Yutaka
- The 1st Departmen of Internal Medicine, St. Marianna University School of Medicine
Bibliographic Information
- Other Title
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- インドメタシン外用製剤の局所的抗炎症作用および経皮吸収
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Description
A jelly-type ointment containing 1% indomethacin, ID gel, was prepared, and the anti-infla-mmatory effects and percutaneous absorption of ID gel were studied. ID gel inhibited carrageenin-induced paw edema concentration-dependently by topical application and showed significant effect at concentratin over 1%. ID gel inhibited inflammation only in the applied foot, but did not influence the edema of non-applied foot in car-rrageenin-induced edema experiments. It was shown that percutaneous absorption of indomethacin was markedly more into the exudate and muscle of the applied foot than those of non-applied foot and systemic blood. ID gel showed also anti-inflam-matory erects on adjuvant arthritis in rats and ultraviolet-induced erythema in guinea pigs.
Journal
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- Ensho
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Ensho 1 (4), 511-514, 1981
The Japanese Society of Inflammation and Regeneration