butyl flufenamate (HF-264) の抗炎症作用機序

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タイトル別名
  • <I>Studies on the anti-inflammatory mechanism of butyl flufenamate (HF-264) </I>

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説明

Anti-inflam-matory mechanism of butyl flufenamate (HF-264) was studied by various analysis. HF-264 did not inhibited the heat denaturation of bovine serum albumin, whereas flufenamic acid showed a marked inhibition on it. HF-264 and flufenamic acid prevented the dog erythrocytes from heat induced lysis, and inhibited the production of superoxide anion in macrophages. HF-264 inhibited the synthesis of prostaglandin E1, but its inhibition of HF-264 on it was more weaker than that of flufenamic acid. From the above results, it is suggested that some part of potent anti-inflammatory action of HF-264 is the results of the interaction of HF-264 with biomembrane, as membrane stabilization and inhibition of superoxide anion production.

収録刊行物

  • 炎症

    炎症 3 (1), 72-74, 1983

    日本炎症・再生医学会

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