Some biochemical properties of the preneoplastic antigen in rat liver hyperplastic nodules

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  • OGINO Masaaki
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • OKITA Kiwamu
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • NAWATA Hiroshi
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • YASUNAGA Mitsuru
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • SHINGAI Yasushi
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • KADO Yuji
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • TSUBOTA Wakako
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • EZAKI Takao
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • NUMA Yoshinori
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • FUKUMOTO Youhei
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • NODA Kenichi
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • KODAMA Takahiro
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
  • TAKEMOTO Tadayoshi
    First Division, Department of Internal Medicine, Yamaguchi University School of Medicine

Bibliographic Information

Other Title
  • ラット肝過形成性結節におけるＰＮ抗原の生化学的性質
  • ラット カン カケイセイセイ ケッセツ ニ オケル PN コウゲン ノ セイカ

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Abstract

Epoxide hydrase (EH), which is one of the drug metabolizing enzymes in the liver, was purified from the rat liver treated with phenobarbital and some biochemical properties of preneoplastic antigen (PN antigen) was investigated with anti EH serum.<BR>Using immunochemical method and sodium dodecyl sulfatepolyacrylamide gel electrophoresis, it was found that PN antigen has the same antigenicity with EH and may be composed of EH and at least one more protein (m.w. 27, 000). Biological properties of such a binding protein to EH are not known so far. However, the existence of PN antigen as EH and its binding protein may be associated with microsomal membrane alterations during chemical carcinogenesis.

Journal

  • Kanzo

    Kanzo 24 (4), 405-411, 1983

    The Japan Society of Hepatology

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