Hepatic tissue oxygenation during degeneration and regeneration of the liver in rats treated with carbon tetrachloride

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  • KAMADA Takenobu
    First Department of Medicine, Osaka University Medical School
  • KISHIDA Yutaka
    First Department of Medicine, Osaka University Medical School
  • SATO Nobuhiro
    First Department of Medicine, Osaka University Medical School
  • MEREN Haruya
    First Department of Medicine, Osaka University Medical School
  • LI Tsue Tgu
    First Department of Medicine, Osaka University Medical School
  • ABE Hiroshi
    First Department of Medicine, Osaka University Medical School

Bibliographic Information

Other Title
  • 肝ｔｉｓｓｕｅ　ｏｘｙｇｅｎａｔｉｏｎと肝障害　　四塩化炭素肝障害の発症と再生，修復過程の解析
  • カン tissue oxygenation ト カン ショウガイ シエンカ タ
  • 四塩化炭素肝障害の発症と再生,修復過程の解析

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Description

The hepatic tissue oxygenation during degeneration and regeneration of the liver was studied in carbon tetrachloride treated rats, using a newly developed tissue oxygen electrode and organ reflectance spectrophotometry. The respiratory activity of the liver slices was also measured in vitro in oxygen electrode apparatus. The results suggest that a decrease of respiratory activity initiates degeneration of liver cells, followed by disturbance of microcirculation and lowering of hepatic tissue oxygen tension. After 48 hours of carbon tetrachloride administration, the respiratory activity improved and the hepatic tissue oxygen tension increased slightly, which may initiate regeneration in accordance with improvement of hepatic microcirculation.

Journal

  • Kanzo

    Kanzo 23 (11), 1249-1255, 1982

    The Japan Society of Hepatology

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