A case of asymptomatic Wilson's disease

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  • HAYASHI Hisao
    The Third Department of Medicine, Nagoya University School of Medicine
  • HUKUI Kazuhiko
    The Third Department of Medicine, Nagoya University School of Medicine
  • MURAKAMI Hiroshi
    The Third Department of Medicine, Nagoya University School of Medicine
  • KURIKI Junsuke
    The Third Department of Medicine, Nagoya University School of Medicine
  • KAKUMU Shinichi
    The Third Department of Medicine, Nagoya University School of Medicine
  • SATO Yuzo
    Research Center of Health, Physical Fitness and Sports, Nagoya University
  • HANAICHI Takamasa
    EM Center, Nagoya University School of Medicine

Bibliographic Information

Other Title
  • 献血を契機に発見された無症候性Ｗｉｌｓｏｎ病の１例
  • ケンケツ オ ケイキ ニ ハッケンサレタ ム ショウコウセイ Wilsonビョ

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Description

A 16 year-old boy was found to have elevated levels of serum transaminases in the screening test of blood donor. He was asymptomatic and family history was negative for liver or neuropsychiatric disorder.<BR>Further examination disclosed a characteristic feature of copper metabolism to Wilson's disease: hypocupremia, hypoceruloplasminemia and increased urinary excretion of copper. But Kayser Fleischer ring and extrapyramidal symptoms were not recognized. The histology of liver consisted with chronic active hepatitis with fatty metamorphosis and glycogen nuclei. Copper concentration was high as 1025μg per gram dry liver weight. A final diagnosis of asymptomatic Wilson's disease was made and D-penicillamine therapy was instituted uneventfully.

Journal

  • Kanzo

    Kanzo 24 (6), 654-658, 1983

    The Japan Society of Hepatology

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