Studies of febuprol induced choleresis in the aspect of bile formation system in the liver

FUKUMOTO Yohei, ODA Masataka, OKITA Kiwamu, ESAKI Takaro, ANDO Keijiro, NUMA Yoshinori, WATANABE Seishiro, NODA Kenichi, KODAMA Takahiro, TAKEMOTO Tadayoshi

doi:10.2957/kanzo.23.885

Febuprol (3-butoxy-1-phenoxy-propanol) is a newly synthesized compound having choleretic effect. As the choleretic mechanism of febuprol is not known sufficiently, its pharmacological effect was estimated experimentally using rats. After injection of febuprol into the duodenum, the elevation of bile volume was detected dose-dependently. Then, the canalicural bile flow was measured in the way of C¹⁴-erythritol clearance in febuprol-administered rats and control rats. More over, by measuring the correlation between bile salt excretion and canalicular bile flow, bile acid dependent flow and bile acid independent flow were estimated. Concentrations of bile acid and minerals in bile were examined, too. As for the evaluation of the influence of febuprol toward drug metabolizing system of the liver, the level of microsomal cytochrome P-450 was studied by the method of Omura and Sato.<BR>Consequently, after administration of febuprol the canalicular bile flow increased as compared with the flow of controls. This action seemed to be due to the elevation of bile acid independent bile flow. In the studies of cytochrome P-450 activity no significant changes were appered by febuprol treatment. This study clarified that febuprol enhanced the bile acid independent canalicular bile flow.

Studies of febuprol induced choleresis in the aspect of bile formation system in the liver

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