Correlation between circulating immune complex and liver-copper levels in the pathogenesis and development of primary biliary cirrhosis

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  • 原発性胆汁性肝硬変の成因および進展機序におよぼすｉｍｍｕｎｅ　ｃｏｍｐｌｅｘおよび肝組織中の銅量についての研究
  • ゲンパツセイ タンジュウセイ カンコウヘン ノ セイイン オヨビ シンテン キ

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Abstract

In order to examine the pathogenesis and development of primary biliary cirrhosis, we measured circulating immune complexes and liver-copper levels in 11 cases of asymptomatic primary biliary cirrhosis (group A) along with 6 cases of symptomatic primary biliary cirrhosis (group B).<BR>Circulating immune complexes detected by the conglutinin solid phase method were found in 70 percent of group A, while 100 percent of the group B exhibited an exceedingly high concentration.<BR>The mean liver-copper levels were 98±46μg/g dry liver for group A, and 1070±68.2μg/g dry liver for group B. A significant difference was obtained in the incidence of livercopper level between the two groups with primary biliary cirrhosis.<BR>Corrleation between the circulating immune complex and liver-copper levels in primary biliary cirrhosis was examined. The circulating immune complex and liver-copper levels were frequently associated.<BR>This result suggests that circulating immune complex and liver-copper levels may be important in the pathogenesis and development of primary biliary cirrhosis.

Journal

  • Kanzo

    Kanzo 22 (5), 717-722, 1981

    The Japan Society of Hepatology

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