Molecular form of IgM antibody to hepatitis B core antigen in sera from the patients with chronic hepatitis B virus infection.

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  • TSUJI Kunihiko
    The Third Department of Internal Medicine, Asahikawa Medical College
  • HASEBE Chitomi
    The Third Department of Internal Medicine, Asahikawa Medical College
  • MURAZUMI Yukari
    The Third Department of Internal Medicine, Asahikawa Medical College
  • YOSHIDA Yukinori
    The Third Department of Internal Medicine, Asahikawa Medical College
  • KANAI Masumi
    The Third Department of Internal Medicine, Asahikawa Medical College
  • OHHIRA Motoyuki
    The Third Department of Internal Medicine, Asahikawa Medical College
  • OHTA Hitoyoshi
    The Third Department of Internal Medicine, Asahikawa Medical College
  • KOHDA Hironobu
    The Third Department of Internal Medicine, Asahikawa Medical College
  • ONO Minoru
    The Third Department of Internal Medicine, Asahikawa Medical College
  • YAZAKI Yasuyuki
    The Third Department of Internal Medicine, Asahikawa Medical College
  • SEKIYA Chihito
    The Third Department of Internal Medicine, Asahikawa Medical College
  • NAMIKI Masayoshi
    The Third Department of Internal Medicine, Asahikawa Medical College

Bibliographic Information

Other Title
  • Ｂ型慢性肝疾患におけるＩｇＭ型ＨＢｃ抗体の分子性状の変化について

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Description

Molecular form of IgM antibody to hepatitis B core antigen (IgM anti-HBc) was analysed by high speed liquid chromatography and enzyme-immunoassay in sera from patients with actue and chronic hepatitis B virus infection<BR>IgM anti-HBc was detected in only 19S IgM with both initial stage and recovery stage of acute hepatitis, but it was detected in not only 19S IgM but also 7S IgM with chronic hepatitis.<BR>Furthermore, 19S IgM was predominant in acute exacerbation phase and conversely 7S IgM was predominant in inactive phase of chronic hepatitis.<BR>These findings suggest that the main molecular form of IgM anti-HBc was changed from 7S IgM to 19S IgM with acute exacerbation of chronic hepatitis.

Journal

  • Kanzo

    Kanzo 32 (1), 1-7, 1991

    The Japan Society of Hepatology

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