A case of primary biliary cirrhosis seronegative for anti-nuclear, anti-mitochodrial antibodies but positive for anti-smooth muscle antibody

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  • 抗ミトコンドリア抗体・抗核抗体が陰性で抗平滑筋抗体が陽性の原発性胆汁性肝硬変の１例
  • 症例報告 抗ミトコンドリア抗体・抗核抗体が陰性で抗平滑筋抗体が陽性の原発性胆汁性肝硬変の1例
  • ショウレイ ホウコク コウミトコンドリア コウタイ コウカク コウタイ ガ インセイ デ コウヘイカツキン コウタイ ガ ヨウセイ ノ ゲンパツセイ タンジュウセイ カンコウヘン ノ 1レイ

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Description

We experienced a case of primary biliary cirrhosis (PBC) seronegative for anti-nuclear and anti-mitochondrial antibodies but positive for anti-smooth muscle antibody. She was a middle-aged woman and asymptomatic. Although laboratory data showed high titer of γ-globurin and IgG and modified AIH score (by International Autoimmune Hepatitis Group, 1999) was 14 which corresponded to probable AIH, she was histologically diagnosed as PBC by typical chronic non-suppurative destructive cholangitis and bile duct injury and lack of interface hepatitis. We think that measurement of anti-smooth muscle antibody may be useful to diagnose PBC in some cases but further studies will be needed to explain the significance of anti-smooth muscle antibody in PBC patients.

Journal

  • Kanzo

    Kanzo 46 (9), 563-569, 2005

    The Japan Society of Hepatology

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