Synthesis of Nascent Peptide Chains (NPC) and DNA of the liver in D-Galactosamine Hepatitis Rats

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  • KANO Takashi
    The First Department of Internal Medicine, Gifu University School of Medicine
  • KOJIMA Takao
    The First Department of Internal Medicine, Gifu University School of Medicine
  • KAWAI Hideko
    The First Department of Internal Medicine, Gifu University School of Medicine
  • SHIMIZU Masaru
    The First Department of Internal Medicine, Gifu University School of Medicine
  • MUTO Yasutoshi
    The First Department of Internal Medicine, Gifu University School of Medicine
  • TAKAHASHI Yoshiyata
    Gifu Prefectural Gifu Hospital

Bibliographic Information

Other Title
  • Ｄ‐Ｇａｌａｃｔｏｓａｍｉｎｅ肝炎ラットにおける肝ｎａｓｃｅｎｔ　ｐｅｐｔｉｄｅ　ｃｈａｉｎｓおよびＤＮＡ合成について　　とくにＧｌｕｃａｇｏｎ‐ＩｎｓｕｌｉｎおよびＰｒｅｄｎｉｓｏｌｏｎｅ投与の影響
  • D Galactosamine カンエン ラット ニ オケル カン nasce
  • とくにGlucagon-InsulinおよびPrednisolone投与の影響

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Abstract

Study was conducted to investigate the synthesis of nascent peptide chains (NPC) on polyribosomes which was reported to be the final destinity of the cell in post-ischemic liver as described by BernelliZazzera, A. (1980).<BR>In D-Galactosamine hepatitis rats, the effects of Glucagon-Insulin (G-I) and prednisolone (PSL) on the synthesis of NPC on free and membrane-bonud polyribosomes were determined, as well as the DNA synthesis and c-AMP contents in liver tissues.<BR>A single dose of G-I elevated maximally the synthesis of NPC on both membrane-bound and free ribosomes 12 and 24 hour after the treatment, respectively. Following the increase in the synthesis of NPC, G-I produced a markedly increase in DNA synthesis in liver tissues 24 hour after the administration.<BR>On the other hand, PSL caused a increase in the synthesis of NPC on polyribosomes only 12 hour after the treatment. However, DNA synthesis was markedly inhibited by PSL.<BR>The administration of G-I produced also a prominent increase in the c-AMP levels of liver tissues as early as 6 hour after the treatment.<BR>These results strongly suggest that synthesis of NPC on polyribosomes plays an important role in repair of cell damage caused by D-Gal and that c-AMP may regulate the synthesis of NPC on polyribosomes and DNA synthesis in liver tissues. Hence, G-I and PSL will prevent the progression of hepatic cell necrosis through increased Synthesis of the NPC on polyribosomes.

Journal

  • Kanzo

    Kanzo 24 (3), 261-270, 1983

    The Japan Society of Hepatology

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