Clinicopathologic study on necrotic nodules in the liver.

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  • NAKASHIMA Hayato
    The First Department of Pathology, Kurume University School of Medicine
  • WATANABE Jiro
    The First Department of Pathology, Kurume University School of Medicine
  • TAGUCHI Jun
    The First Department of Pathology, Kurume University School of Medicine
  • OKUDAIRA Sadayuki
    The First Department of Pathology, Kurume University School of Medicine
  • NAKASHIMA Yutaka
    The First Department of Pathology, Kurume University School of Medicine
  • YASUNAGA Masafumi
    The First Department of Pathology, Kurume University School of Medicine
  • IHA Hayato
    The First Department of Pathology, Kurume University School of Medicine
  • KOJIRO Masamichi
    The First Department of Pathology, Kurume University School of Medicine
  • TANAKA Masatoshi
    The Second Department of Internal Medicine, Kurume University School of Medicine
  • MAJIMA Yasuo
    The Second Department of Internal Medicine, Kurume University School of Medicine
  • TANIKAWA Kyuichi
    The Second Department of Internal Medicine, Kurume University School of Medicine
  • TANIWAKI Satoshi
    The Second Department of Internal Medicine, Kurume University School of Medicine
  • SAITSU Hideki
    The Second Department of Internal Medicine, Kurume University School of Medicine
  • NAKAYAMA Toshimichi
    The Second Department of Internal Medicine, Kurume University School of Medicine

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Other Title
  • 肝の凝固壊死を呈する肉芽性結節に関する臨床病理学的研究

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Description

Recently, it is not uncommon to encounter a single or multinodular lesions consisting solely of coagulative necrosis and it is rather difficult to make a definitive pathologic diagnosis with biopsy specimens and/or resected specimens. We have studied 14 cases of necrotic nodule of the liver to clarify the clinicopathologic characteristics. All the nodules were detected as a hypoechoic tumor and 2 echogenic lines (bead sign) were observed in 10 out of the 14 nodules. As to hepatitis virus markers, Hepatitis B surface antigen was negative in all cases and two cases were found to be positive for hepatitis C virus antibody. Morphologically, the nodules consisted of varying degrees of coagulative necrosis surrounded by a thin layer of granulation tissue. In coagulative necrosis, numerous eosinophils and Charctor-Leyden crystals were recognized in 7 nodules (50%), respectively. Accordingly, it was predicted that the nodules were closely rerated to parasitic infections including toxocariasis and fasciola hepatica.

Journal

  • Kanzo

    Kanzo 35 (7), 527-535, 1994

    The Japan Society of Hepatology

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