A clinicopathological study in patients with seroconversion from e antigen to e antibody in HBsAg positive chronic active hepatitis.
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- HATTORI Nobu
- The First Department of Internal Medicine, School of Medicine, Kanazawa University
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- NAKANUMA Yasuji
- The Second Department of Pathology, Kanazawa University
Bibliographic Information
- Other Title
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- B型慢性活動性肝炎におけるe抗原からe抗体へのSeroconversionの臨床病理学的研究
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Abstract
A clinicopathological study was carried out in patients with seroconversion from e antigen to e antibody in HBsAg positive chronic active hepatitis. Liver biopsy specimens were obtained from 7-CAH patients during the positive e antigen and all showed histological features comprised of severe portal inflammation, picemeal necrosis, rosettes formation, ballooning of hepatocytes and parenchymal inflammation, even with lobular dysorganization. In all the 7 patients with chronic active hepatitis in the initial biopsy who seroconverted, liver histology and change during the follow up period: 2 of them developed histological features of superimposed cirrhosis, one of them remained unchanged while the other 4 showed regression to chronic persistent hepatitis. In patients with seroconversion from e antigen to e antibody, subjects biopsies remained improved histological features comprised of portal inflammation, picemeal necrosis, rosettes formation, parenchymal inflammation and ballooning of hepatocytes.
Journal
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- Kanzo
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Kanzo 26 (8), 987-992, 1985
The Japan Society of Hepatology
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Keywords
Details 詳細情報について
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- CRID
- 1390282679767686400
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- NII Article ID
- 130000880697
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- ISSN
- 18813593
- 04514203
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed