A case of autoimmune hepatitis with positive anticentromere antibody associated with a limited type of scleroderma and chronic thyroiditis.

OHMOTO Kenji, MIYAKE Ichiro, IGUCHI Yasutaka, OHNO Seiichi, MITSUI Yasuhiro, SHIMABARA Masakiyo, IDEGUCHI Seiji, KUBOKI Makoto, SHIBATA Norikuni, YAMAMOTO Shinichiro, HIROKAWA Mitsuyoshi, HIRANO Yutaka

doi:10.2957/kanzo.37.638

A 60-year-old female was admitted to our hospital because of jaundice with complaints of general fatigue and anorexia. She did not drink alcohol or take medicine. On admission, liver fucntion tests revealed elevation of total bilirubin and transaminase, concomitantly with hypergammaglobulinemia. Virus markers were negative for hepatitis A, B and C. Serum antinuclear antibody and anticentromere antibody (ACA) were positive, but LE cells were not detected. A liver biopsy specimen showed chronic active hepatitis. Thereafter, 30mg prednisolone was prescribed and rapid improvement was observed in transaminase, total bilirubin and gammaglobulin.<BR>She had also been aware of Raynaud's phenomenon for a few years and complained of sclerodactylia, which were features of a limited type of scleroderma. In addition, serological examination showed high antithyroglobulin and antimicrosome antibody titers. Further studies of her thyroid function, revealed that she suffered from occult chronic thyroiditis.<BR>The coexistence of autoimmune hepatitis with a limited type of scleroderma and chronic thyroiditis is quite rare. ACA was detected in her serum. ACA seemed to be related to the pathogenesis of these diseases.

A case of autoimmune hepatitis with positive anticentromere antibody associated with a limited type of scleroderma and chronic thyroiditis.

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