A case of sporadic porphyria cutanea tarda in heavy drinker associated with hepatitis C virus infection.

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  • Ｃ型肝炎ウイルス感染を有する大酒家にみられた散発性晩発性皮膚ポルフィリン症の１例

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A 48-year-old man with sporadic porphyria cutanea tarda (S-PCT) associated with hepatitis C virus (HCV) infection is reported.<BR>The patient had a history of excessive alcohol (AL) intake and blood transfusion. Serological tests for anti-HCV antibody and HCV RNA demonstrated persistent HCV infection. Blood chemistry showed abnormality in the levels of transaminases and γ-glutamyl transpeptidase. In a biopsy specimen from the liver, histological features of chronic active hepatitis, including piecemeal necrosis and spotty necrosis was observed, indicating possible involvement of HCV infection. Histological features of pericellular fibrosis and central sclerosis that suggest alcoholic liver disease (ALD) was also present. In addition, a moderate deposition of hemosiderin and lipofuscin was recognized in hepatocytes and Kupffer's cells. HCV and AL were thus considered to be involved in main etiology of the patient's chronic liver disease.<BR>Taken together, the simultaneous presence of chronic hepatitis, ALD and hemosiderin deposit in a liver biopsy specimen from a heavy drinker with HCV infection is considered as an important histological finding which suggests PCT under routine, light microscopical observation.

Journal

  • Kanzo

    Kanzo 37 (10), 572-579, 1996

    The Japan Society of Hepatology

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