Effects of anti-HBs human immunoglobulin for accidental exposures among medical staffs

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Other Title
  • ＨＢＶ感染事故に対する抗ＨＢｓヒト免疫グロブリンの使用経験
  • HBV カンセン ジコ ニ タイスル コウ HBsジン メンエキ グロブリン

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Description

Forty-one medical staffs accidentally exposed to HBs-antigen positive blood were given anti-HBs human immunoglobulin (HBIG) intramuscularly within 48 hours after exposure. They were followed with tests for HBs antigen, anti-HBs and transaminases in sera at intervals of two weeks for 6 months. Anti-HBc was determined on the sera obtained just before the HBIG injection and the final sera of the follow-up. All the staffs except for one had neither HBs antigen, anti-HBc detected nor transaminases increased in sera during the follow-up periods. Anti-HBs were raised up to 1: 16 to 1: 64 with PHA titer two weeks after the injection of HBIG and disappeared two to three months later.<BR>One of the staffs, a 26 year-old nurse treated with HBIG, acquired acute type B hepatitis 19 weeks after exposure to HBe antigen positive blood. The HBs antigen subtype was identical with that of the source of infection. A similar case was subsequently experienced in a 32year-old female doctor belonging to another hospital. She was exposed to HBe antigen positive blood, and attacked with acute type B hepatitis 30 weeks after exposure in spite of receiving a HBIG injection. These two cases indicate that HBIG might not completely protect the occurrence of acute hepatitis after accidental exposure to HBe positive blood, and that follow-up after the HBIG injection should be continued at least for 9 months, since the incubation time of the acute type B hepatitis would be prolonged.

Journal

  • Kanzo

    Kanzo 22 (3), 391-396, 1981

    The Japan Society of Hepatology

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