Clinical studies on the cases of anti-HBe-positive chronic hepatitis with acute exacerbation

NISHIHARA Takashi, YAMADA Gotaro, MIZUNO Motowo, SAKAMOTO Yuzi, KINOYAMA Shingo, NAGASHIMA Hideo

doi:10.2957/kanzo.23.1133

Out of twenty-two patients with chronic liver disease who had been positive for HBsAg and anti-HBe during more than 6 months, 5 patients with chronic hepatitis showed high elevation of s-GPT. Increase in DNA polymerase (DNA-P) activity and appearance of Dane particles in sera were recognized in 4 of these 5 patients. In one case, values of anti-HBe became transiently judge-pended at the time of exacerbation, though being stationary in remaining 3 cases. In the immunohistological study of a liver biopsy specimen from one of these cases, cytoplasmic HBsAg was diffusely distributed, but HBcAg was rarely recognized. In the fifth case, however, the simultaneous infection with non-A, non-B hepatitis virus in a carrier of hepatitis B virus was suspected, because the patient was transfused in operation about 2 months before the developed acute exacerbation without increase of DNA-P activity. On the other hand, 17 of 22 cases showed normal s-GPT and no appearance of DNA-P activity in their sera.

Clinical studies on the cases of anti-HBe-positive chronic hepatitis with acute exacerbation

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