Effect of exogenous mouse interferon on murine fulminant hepatitis induced by Mouse Hepatitis Virus (MHV)-2

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  • NODA Yatsugi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • KATO Yasuhiro
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • UNOURA Masashi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • TANAKA Nobuyoshi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • KOBAYASHI Kenichi
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • HATTORI Nobu
    The First Department of Internal Medicine, School of Medicine, Kanazawa University
  • HATANO Kiichi
    The Department of Virology, Cancer Research Institute, Kanazawa University
  • KOBAYASHI Shigeyasu
    Toray industries, Inc. Basic Research Laboratories

Bibliographic Information

Other Title
  • マウスＭＨＶ‐２劇症肝炎モデルに対するマウスインターフェロンの投与効果

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Abstract

We investigated the effect of exogenous mouse interferon produced by L-cell on the growth of MHV-2 in the liver tissue, the progression of liver cell necrosis, and the subsequent survival time in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was made in 4-week-old male ICR (SPF) mice by the intraperitoneal inoculation of MHV-2 (105/PFU/mouse). Mouse interferon (103/IU/Mouse/day) was intraperitoneally injected every day. MHV-2 in the liver tissue was plaque assayed using DBT-cell after homogenization of the liver tissue. Exogenous mouse interferon suppressed both the growth of MHV-2 in the liver tissue and the progression of liver cell necrosis, and also prolonged survival time. Regarding survival time, the earlier the injection of mouse interferon was started, the longer survival time was increased.

Journal

  • Kanzo

    Kanzo 25 (1), 18-23, 1984

    The Japan Society of Hepatology

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