Studies of serum binding-protein to Sulfobromophthalein (BSP) and Indocyanine green (ICG), and its clinical estimation

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  • YATSUJI Yukinobu
    The second Department of Internal Medicine, Faculty of Medicine, Tokyo University
  • HIRANO Masanori
    The second Department of Internal Medicine, Faculty of Medicine, Tokyo University
  • KAMISAKA Kazuaki
    The second Department of Internal Medicine, Faculty of Medicine, Tokyo University
  • MOTOKI Tatsuya
    The second Department of Internal Medicine, Faculty of Medicine, Tokyo University
  • MURAO Satoru
    The second Department of Internal Medicine, Faculty of Medicine, Tokyo University
  • YAMADA Hideo
    Department of Nuclear Medicine and Radiological Science, Tokyo Metropolitan Geriatric Hospital
  • KAMEDA Haruo
    The First Department of Internal Medicine, Tokyo Jikei University, School of Medicine

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Other Title
  • BSP・ICG結合血清蛋白の検討およびその臨床的意義
  • BSP ICG ケツゴウ ケッセイ タンパク ノ ケントウ オヨビ ソノ リン

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Abstract

After intravenous administration, BSP and ICG are rapidly bound to serum protein. For the purpose of identifying the fraction of binding protein for BSP and ICG, column chromatography of sephadex G 200, single radial immunodiffusion in serum containing gels and agarose-gel electrophoresis were performed. The result showed that BSP was mainly bound to albumin and ICG was mainly to lipoprotein, especiallyβ-lipoprotein.<BR>In order to study the influence of plasma protein change on dye clearance, plasma disappearance rate of BSP and ICG were studied in 16 patients with hypoalbuminemia (less than 2.5%), but without proven liver disease, such as nephrotic syndrome, lung cancer, gastric cancer and protein loosing gastroenteropathy. There was high correlation between BSP clearance rate and serum albumin level (γ=-0.603, p<0.01), while the coefficient of correlation between ICG clearance rate and serum albumin level was low (γ=-0.331, p<0.05).

Journal

  • Kanzo

    Kanzo 16 (11), 763-769, 1975

    The Japan Society of Hepatology

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