The utility of natural human interferon.BETA. in a case of chronic hepatitis C with a history of peg-interferon.ALPHA.2a related erythema multiforme

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Other Title
  • ペグインターフェロンα２ａ単独投与中に多型紅斑型薬疹を生じたＣ型慢性肝炎に対し天然型インターフェロンβ製剤の投与によりウイルス排除が得られた１例
  • 症例報告 ペグインターフェロンα2a単独投与中に多型紅斑型薬疹を生じたC型慢性肝炎に対し天然型インターフェロンβ製剤の投与によりウイルス排除が得られた1例
  • ショウレイ ホウコク ペグインターフェロン アルファ 2a タンドク トウヨ チュウ ニ タケイコウ ハンガタヤクシン オ ショウジタ Cガタ マンセイ カンエン ニ タイシ テンネンガタ インターフェロン ベータ セイザイ ノ トウヨ ニ ヨリ ウイルス ハイジョ ガ エラレタ 1レイ
  • The utility of natural human interferonβ in a case of chronic hepatitis C with a history of peg-interferonα2a related erythema multiforme

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Description

A sixty-four-year-old woman received anti-viral therapy with peg-interferon alpha 2a. Erythema was detected in her upper arm after the fourth administration; then the erythema spread widely over the body in a few weeks. Peg-interferon therapy was promptly discontinued. After being admitted to our hospital she was diagnosed with erythema multiforme induced by peg-interferon alpha 2a. After her erythema multiforme had been resolved by administering internal prednisolone and topical corticosteroid, an antiviral therapy of intravenous natural human interferon beta was initiated without any major side effect or cutaneous symptoms. The patient was eventually able to achieve a sustained viral response. Natural human intravenous interferon beta is considered to be an antiviral therapy for the treatment of chronic hepatitis C patients with severe cutaneous symptoms because of the administration of peg-interferon.<br>

Journal

  • Kanzo

    Kanzo 51 (3), 112-118, 2010

    The Japan Society of Hepatology

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