Studies on clinical significance of lipoprotein-X in the liver diseases

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  • TAKENAMI Toshihiko
    First Division. Department of Internal Medicine, Yamaguchi University School of Medicidne

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Other Title
  • 肝障害時のlipoprotein-X出現の意義に関する研究
  • カン ショウガイジ ノ lipoprotein X シュツゲン ノ イギ ニカ
  • (I) Appearance of an abnormal lipoprotein in rats with experimental cholestasis
  • (I) 実験肝障害と異常リポ蛋白

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Abstract

This study was carried out with D-galactosamine administrated rats and bile duct ligated rats, in order to throw some lights on the relationship between appearance of abnormal lipoprotein (Ab-Lp) and liver function. By the changes of liver function and histological findings, both animals showed liver injury with cholestasis. Then, Ab-Lp was detected in the sera of both animals by Bacto-agar electrophoresis. Electrophoretic patterns of these Ab-Lp seemed to be the same with rat lipoprotein-X which was reported by some investigators. As the conclusion, the appearance of Ab-Lp in the blood is closely related to cholestatic condition of the liver. However, the direct evidence of the mechanism of Ab-Lp formation is still remained unclear.

Journal

  • Kanzo

    Kanzo 19 (1), 43-51, 1978

    The Japan Society of Hepatology

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