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- 松田 彰史
- 山口大学医学部第1内科
書誌事項
- タイトル別名
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- Glucagon-insulin therapy for the treatment of acute liver failure (2) changes of biological parameters after glucagon-insulin therapy in the severe hepatitis bearing rats
- キュウセイ カンフゼン ニ タイスル glucagon insulin リョウ
この論文をさがす
説明
Our previous reports have made clear that glucagon and insulin stimulate the liver regeneration by their synergistic action in experimental and clinical trials.<BR>In this paper we aimed to reveal interaction of their pancreatic hormones to molecular levels in the damaged liver.<BR>Rats were administered of d-galactosamine (1000mg/kg body weight) by intraperitoneal injection. After 24 hours we treated with administration of glucagon (1mg/kg body weight) and regular insulin (1unit/kg body weight).<BR>These rats were divided into three groups as the followes; glucagon-insulin group, glucagon group and control group.<BR>After studying of the biological parameters for the liver regeneration, we revealed positively the localization of alpha-fetoprotein, cyclic AMP by immunofluorescence method in liver tissue and DNA synthesis in vivo by autoradiography of 3H-thymidine.<BR>Survivors were significantly enhanced with administration of glucagon and insulin in comparison to glucagon alone and control.<BR>It is concluded that administration of glucagon and insulin simultaneously stimulate the biological parameters and improve the survival rate.
収録刊行物
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- 肝臓
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肝臓 21 (9), 1125-1134, 1980
一般社団法人 日本肝臓学会
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詳細情報 詳細情報について
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- CRID
- 1390282679769455872
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- NII論文ID
- 130000876974
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- NII書誌ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL書誌ID
- 2223655
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可