Studies on the mitochondrial and microsomal cytochromes in alcoholics liver

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  • KAMADA Takenobu
    The First Department of Internal Medicine, Osaka University Medical School
  • SATO Nobuhiro
    The First Department of Internal Medicine, Osaka University Medical School
  • KAWANO Sunao
    The First Department of Internal Medicine, Osaka University Medical School
  • HAYASHI Norio
    The First Department of Internal Medicine, Osaka University Medical School
  • KISHIDA Takashi
    The First Department of Internal Medicine, Osaka University Medical School
  • MATSUMURA Takamasa
    The First Department of Internal Medicine, Osaka University Medical School
  • SUEMATSU Toshihiko
    The First Department of Internal Medicine, Osaka University Medical School
  • ABE Hiroshi
    The First Department of Internal Medicine, Osaka University Medical School
  • TAKAOKA Yoshiaki
    The Department of Internal Medicine, Osaka Prefectural Hospital
  • KOJIMA Junnosuke
    The Department of Internal Medicine, Center for Adult Diseases
  • HAGIHARA Bunji
    The Department of Biochemistry, Osaka University Medical School

Bibliographic Information

Other Title
  • 飲酒者の肝臓ミトコンドリアならびにミクロゾーム酵素の量的変動に関する研究
  • インシュシャ ノ カンゾウ ミトコンドリア ナラビニ ミクロゾーム コウソ ノ

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Abstract

The mitochondrial and microsomal cytochromes in human livers were studied in relation to the ethanol metabolism. For this purpose, a micromethod for determining the cytochromes content in small biopsy sample was developed. The results with 62 cases with a variety of liver diseases were as follows; 1) The liver cytochrome a3 content did not significantly change in the drinkers with chronic hepatitis (CH) as compared to that of the non-drinkers, while it slightly decreased in the case of liver cirrhosis (LC), 2) The cytochrome P-450 content significantly increased in the drinkers with CH(P<0.05), while no change was observed in the drinkers with LC, 3) the P-450/b5 ratio of non-drinkers' livers was found to be in linear correlation, while this ratio was variable in the drinkers. The results were discussed in view of the ethanol metabolism in the livers.

Journal

  • Kanzo

    Kanzo 18 (12), 943-949, 1977

    The Japan Society of Hepatology

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