Studies on ammonia metabolism in the rat liver in biliary obstruction

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  • OHWADA Yasuo
    The First Department of Surgery Tohoku University School of Medicine
  • KOYAMA Kenji
    The First Department of Surgery Tohoku University School of Medicine
  • TAKAGI Yasushi
    The First Department of Surgery Tohoku University School of Medicine
  • ANEZAKI Takumi
    The First Department of Surgery Tohoku University School of Medicine
  • 佐藤 寿雄
    東北大学医学部第一外科教室

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Other Title
  • 閉塞性黄疸肝におけるアンモニア代謝について
  • ヘイソクセイ オウダン カン ニ オケル アンモニア タイシャ ニ ツイテ

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Description

In order to clarify the ammonia metabolism in the rat liver in both biliary obstruction and carbon-tetrachloride (CCl4) injection, urea synthesis and ammonia removal in liver slices and arginine synthetase activity in liver homogenate were examined. Following results were obtained : <BR>1) In biliary obstruction groups, urea synthesis and ammonia removal in liver slices were decreased with the duration of biliary obstruction. The increasing rate in urea synthesis and ammonia removal by addition of ATP and ornithine in the medium was also declined, especially in the 6-week group. Arginine synthetase activity was decreased progressively corresponding to the duration with its lowest in 6-week group. <BR>2) In CCl4 group, no remarkable decrease in arginine synthetase activity was illustrated compared with 6-week group, however, the grade of urea synthesis and ammonia removal in liver slices were distinctly decreased, which were accelerated prominently in the presence of ATP and ornithine.

Journal

  • Kanzo

    Kanzo 18 (5), 333-340, 1977

    The Japan Society of Hepatology

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