特発性門脈圧亢進症に於ける肝内異常血行路の研究

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タイトル別名
  • Abnormal vascular system in the liver of Banti's disease
  • トクハツセイ モンミャクアツ コウシンショウ ニ オケル カンナイ イジョウ

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Banti's disease, supposedly a disease entity in Japan, is characterized by presence of portal hypertension (splenomegaly and esophageal varices) and hypersplenism (anemia, leucopenia and thrombocytopenia). The etiology is unknown, and similar cases with portal hypertension and hypersplenism due to an apparent etiology (e.g. schistosomiasis and cirrhosis) are excluded. The underlying pathological features are either liver fibrosis or early cirrhosis (Miyake's B'). Pathogenesis of portal hypertension is thought to be narrowing and/or occlusion of terminal branches of portal veins (intrahepatic). In cases, however, those findings are not so conspicuous, and to the contrary markedly dilated vessels are remarkable findings. In this study, microscopic observation of these vessels on serial sections disclosed dilated abnormal inletvenules located at the periphery of Glisson's sheath which connect proliferated arterioles in Glisson's sheath and dilated sinusoids and central veins. We suspect this abnormal flow or shunt, apparently different from the normal hepatic vascular system, play an important role on pathogenesis of portal hypertension in Banti's disease.

収録刊行物

  • 肝臓

    肝臓 18 (11), 814-820, 1977

    一般社団法人　日本肝臓学会

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